Thermo Fisher Scientific CD197 (CCR7) Monoclonal Antibody (3D12), PE, eBioscience
인간 CCR7(CD197)을 인식하는 3D12 클론의 단클론 항체로, PE로 표지되어 있습니다. 유세포분석(Flow Cytometry)에 적합하며, T 세포 및 수지상세포의 분화·이주 연구에 활용됩니다. 4°C에서 보관하며 동결 금지.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (0.125 µg)/test
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3D12 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10667886 |
Additional Formats Available
- Unconjugated
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 395 / 563 / 661 / 737
- Brilliant Violet 421 / 480 / 711 / 786
- FITC
- NovaFluor Red 685 / 700 / 755
- NovaFluor Yellow 700
- PE-Cyanine5.5 / PE-Cyanine7 / PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 600 / 645 / 780
- Request custom conjugation
Product Specific Information
The 3D12 monoclonal antibody reacts with human CCR7 (CD197), also known as EBI-1.
CCR7 is a G-protein-coupled chemokine receptor with seven membrane-spanning domains and serves as a receptor for CCL19 and CCL21. It is expressed on T cells and dendritic cells (DCs) and is used to distinguish naive, central, and effector memory T cell populations.
During DC maturation, CCR7 expression increases and contributes to functions such as:
- Chemotaxis to lymph nodes
- Cellular architecture and endocytosis regulation
- Survival and maturation
Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and validated for human peripheral blood cells at 5 µL (0.125 µg)/test.
Optimal staining: Incubate ≥45 minutes at 2–8°C.
Excitation: 488–561 nm
Emission: 578 nm
Compatible Lasers: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CCR7 belongs to the G protein-coupled receptor family and is induced by Epstein-Barr virus (EBV).
It is expressed in blood, bone marrow, lymph nodes, and intestines, particularly in lymphoid tissues and activated B/T lymphocytes. CCR7 regulates migration of memory T cells to inflamed tissues and promotes dendritic cell maturation.
Its specific ligands include CCL19 (ECL) and CCL21.
C-C chemokine receptors such as CCR1–CCR5 and the Duffy antigen are crucial for T cell chemotaxis and phagocyte migration during inflammation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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