Thermo Fisher Scientific CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), Functional Grade, eBioscience
Thermo Fisher Scientific의 eBioMWReg30 (MWReg30) CD41a 단클론 항체는 마우스 CD41을 인식하며, 혈소판 및 조혈 줄기세포 연구에 적합합니다. Flow cytometry 및 기능적 분석에 최적화되어 있으며, 4°C에서 보관됩니다. 고순도(>90%) 및 저엔도톡신(<0.001 ng/µg) 수준을 제공합니다.
- 카탈로그번호
- 16-0411-xxx (4개 옵션)
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- pk
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4개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), Functional Grade, eBioscience
Thermo Fisher Scientific CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), Functional Grade, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | 1 publication |
| Immunohistochemistry (IHC) | - | 5 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | - | 2 publications |
| Immunocytochemistry (ICC/IF) | - | 7 publications |
| Flow Cytometry (Flow) | 0.25 µg/test | 41 publications |
| ELISA | - | 1 publication |
| Immunoprecipitation (IP) | - | 1 publication |
| Functional Assay | Assay-dependent | 1 publication |
| Peptide Array | - | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Hamster, Human, Mouse |
| Host/Isotype | Rat / IgG1, kappa |
| Recommended Isotype Control | Rat IgG1 kappa Isotype Control (eBRG1), Functional Grade, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioMWReg30 (MWReg30) |
| Conjugate | Functional Grade |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
| RRID | AB_2865723 |
Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- eFluor 450
- FITC
- NovaFluor Blue 510
- NovaFluor Blue 555
- NovaFluor Blue 660-120S
- NovaFluor Yellow 570
- NovaFluor Yellow 660
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Request custom conjugation available
Product Specific Information
The eBioMWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alpha IIb). CD41 is expressed on platelets, megakaryocytes, and hematopoietic progenitors. It associates with CD61 (gpIIIa, integrin beta III) to form a receptor crucial for platelet adhesion and aggregation via fibrinogen, fibronectin, and vitronectin binding.
CD41 expression is useful for identifying hematopoietic stem cells (HSCs) when combined with SLAM-family markers CD48 and CD150. CD150⁺CD48⁻CD41⁻ cells are highly efficient in long-term multilineage reconstitution.
- Applications Reported: Flow cytometry and functional assays
- Applications Tested: Flow cytometric analysis of mouse platelets at ≤0.25 µg/test (100 µL volume, 10⁵–10⁸ cells/test; titrate for optimal performance)
Storage and Handling: Use in sterile environment.
Filtration: 0.2 µm post-manufacturing filtered.
Purity: >90% (SDS-PAGE).
Endotoxin Level: <0.001 ng/µg antibody (LAL assay).
Aggregation: <10% (HPLC).
Target Information
CD41 (platelet glycoprotein IIb, ITGA2B) consists of alpha (120 kDa) and beta (23 kDa) subunits that interact with CD61 in the presence of calcium to form a functional adhesive receptor. It mediates platelet aggregation and binds to von Willebrand factor, fibrinogen, fibronectin, and vitronectin. CD41 is mainly expressed in the megakaryocyte-platelet lineage and during early hematopoietic differentiation.
Associated diseases include Glanzmann Thrombasthenia and Platelet type-16 bleeding disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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