Thermo Fisher Scientific PDGFRB Monoclonal Antibody (18A2), APC
인간 PDGFRB(CD140b)를 인식하는 마우스 단클론 항체로, APC 형광체로 결합되어 유세포분석(Flow Cytometry)에 적합합니다. 4°C 암소 보관하며, 세포 표면 PDGFRB 발현 분석에 유용합니다.
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Applications
- Flow Cytometry (Flow): 10 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 18A2 |
| Immunogen | CD140b-transfected NIH 3T3 cells |
| Conjugate | APC (Allophycocyanin) |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153969 |
Additional Formats
- Unconjugated (Cat. MA1-10100)
- PE conjugated (Cat. MA1-10102)
- Custom conjugation available upon request
Product Specific Information
This antibody recognizes an extracellular epitope of CD140b / PDGF-RB, the 180–190 kDa beta chain of platelet-derived growth factor receptor. It is widely expressed on mesenchymal-derived cells and plays pro-proliferative roles.
Target Information
PDGFRB is a receptor tyrosine kinase implicated in atherogenesis and cell transformation by the SIS oncogene. These growth factors act as mitogens for mesenchymal-origin cells. The receptor can form homodimers or heterodimers with PDGFRA depending on the ligand. The gene is located on chromosome 5, near GM-CSF and M-CSFR genes, and is associated with the 5q- syndrome. A translocation between chromosomes 5 and 12 (PDGFRB–ETV6 fusion) causes chronic myeloproliferative disorders with eosinophilia.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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