Thermo Fisher Scientific PDGFRB Monoclonal Antibody (18A2)
인간 PDGFRB(CD140b)를 인식하는 Mouse IgG1 단일클론 항체로, 세포면 수용체 분석에 적합합니다. ICC/IF 및 유세포분석에 사용 가능하며, Protein A로 정제된 액상 형태입니다. 4°C 보관, 동결 금지.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1–4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 18A2 |
| Immunogen | CD140b-transfected NIH 3T3 cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153765 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular epitope of CD140b / PDGF-RB, the 180–190 kDa beta chain of platelet-derived growth factor receptor. It is widely expressed on mesenchymal-derived cells and plays pro-proliferative roles.
Target Information
PDGFRB is a receptor tyrosine kinase implicated in atherogenesis and cell transformation by the SIS oncogene. These growth factors act as mitogens for cells of mesenchymal origin. The identity of the bound growth factor determines whether the receptor forms a homodimer or heterodimer with PDGFRA. The PDGFRB gene is located on chromosome 5, near genes for GM-CSF and M-CSF receptor, and may be involved in the 5-q syndrome. A translocation between chromosomes 5 and 12 fusing PDGFRB (CD140b) and ETV6 genes is associated with chronic myeloproliferative disorder with eosinophilia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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