Thermo Fisher Scientific IL-17A Monoclonal Antibody (eBio64DEC17), APC, eBioscience
인간 IL-17A를 인식하는 중화 단일클론 항체로, APC 형광표지되어 유세포분석에 적합합니다. Th17 세포 연구, 염증성 질환 및 면역 반응 분석에 활용됩니다. 633–647 nm 레이저로 여기되며, 660 nm에서 방출됩니다. 4°C 암소 보관, 동결 금지.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IL-17A Monoclonal Antibody (eBio64DEC17), APC, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 5 µL (0.06 µg)/test | View 27 publications |
| Functional Assay | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Fungi, Human, Mouse, Rhesus monkey |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio64DEC17 |
| Conjugate | APC |
| Excitation/Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1582222 |
Additional Available Formats
- Unconjugated
- Alexa Fluor 488
- APC-eFluor 780
- Biotin
- Brilliant UV 563
- Brilliant UV 737
- Brilliant UV 805
- Brilliant Violet 605
- Brilliant Violet 786
- eFluor 450
- eFluor 506
- eFluor 660
- FITC
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-Cyanine5.5
- Request custom conjugation
Product Specific Information
The eBio64DEC17 antibody reacts with human IL-17A and functions as a neutralizing antibody. IL-17A is a CD4+ T cell-derived cytokine that promotes inflammatory responses and is elevated in conditions such as rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection.
Human IL-17A exists as glycosylated 20–30 kDa homodimers produced by activated CD4+ T-cells. It enhances ICAM-1 expression in fibroblasts and stimulates epithelial, endothelial, and fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of IL-17A, fibroblasts support CD34+ progenitor proliferation and neutrophil maturation.
IL-23-dependent, IL-17A-producing CD4+ T cells (Th17 cells) represent a distinct subset from Th1 and Th2 cells. IFN-γ and IL-4 negatively regulate Th17 differentiation.
Intracellular staining by eBio64DEC17 identifies the same population as eBio64CAP17 in co-staining experiments.
Applications Reported: Intracellular staining followed by flow cytometric analysis.
Applications Tested: Pre-titrated for intracellular staining and flow cytometry of stimulated human peripheral blood cells.
Recommended usage: 5 µL (0.06 µg) per test in 100 µL final volume. Cell number: 10⁵–10⁸ cells/test.
Excitation: 633–647 nm; Emission: 660 nm; Laser: Red.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
Interleukin-17A (IL-17A, CTLA-8) is a 32 kDa disulfide-linked homodimer of 136 amino acids, a member of the IL-17 family (A–F). It signals through IL-17R (CDw217) and regulates NF-κB and MAPK pathways, stimulating IL-6 and COX-2 expression and nitric oxide production. IL-17A plays key roles in inflammatory and autoimmune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.