Thermo Fisher Scientific CD49c (Integrin alpha 3) Monoclonal Antibody (ASC-1)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody recognizes an extracellular epitope of CD49c (integrin alpha 3), a transmembrane glycoprotein composed of disulfide-linked 125 kDa and 30 kDa chains. It is expressed on adherent cell lines and to a lesser extent on T and B cells and monocytes.

Target Information

ITGA3 (INTEGRIN, ALPHA-3), also known as CD49C, VLA3, or GAPB3, is encoded by the ITGA3 gene in humans. It is an integrin alpha subunit and a member of the cell surface adhesion molecule family.

• Chromosomal location: 17q21.33
• Forms the alpha3beta1 integrin duplex involved in neural migration and corticogenesis with the beta-1 subunit.
• Plays a role in DAB1 phosphorylation and ITGA3 signaling for neuronal detachment from radial glial fibers.
• Expression of human ITGA3 increases viral infectivity in Chinese hamster ovary cells.
• Contains 13 potential N-glycosylation sites, 2 cleavage sites, and 7 N-terminal repeating units typical of ITGAs.
• Recombinant ITGA3 is expressed as a 150-kD protein, consistent with the native form in western blot analysis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.