Thermo Fisher Scientific CD56 Monoclonal Antibody (56C04)
CD56 단클론 항체(56C04)는 인간 및 랫트 시료에서 CD56 검출에 사용되며, WB, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합합니다. 소세포 폐암 세포막 유래 항원으로 제작된 IgG1 항체로, 높은 특이성과 신뢰성을 제공합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100–1:500 | View 3 publications |
| Immunohistochemistry (IHC) | – | View 8 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL | View 2 publications |
| Immunocytochemistry (ICC/IF) | 1:10–1:200 | View 1 publication |
| Flow Cytometry (Flow) | 0.5 µg/test | View publications |
| Immunoprecipitation (IP) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 56C04 |
| Immunogen | Membrane preparation of a small cell lung carcinoma |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10985168 |
Product Specific Information
MA5-11563 targets CD56 in IHC (P), Western blot, ICC/IF, and FACS applications and shows reactivity with Human and Rat samples.
The MA5-11563 immunogen is a membrane preparation of a small cell lung carcinoma.
Target Information
CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that functions as an adhesive molecule and is ubiquitously expressed in the nervous system in isoforms ranging from 120–180 kDa.
CD56 is found on T cells and NK cells, and is involved in cell migration, axonal growth, pathfinding, and synaptic plasticity. Polysialic modification reduces CD56-mediated cell adhesion.
Through its extracellular region, CD56 mediates homophilic and heterophilic interactions by binding extracellular matrix components such as laminin and integrins.
CD56 is expressed on most neuroectodermal-derived cell lines, tissues, and neoplasms such as retinoblastoma, medulloblastoma, astrocytomas, and neuroblastoma. It is a widely used neuroendocrine marker with high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors.
Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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