Thermo Fisher Scientific MBP Monoclonal Antibody (2H9)

Thermo Fisher Scientific MBP Monoclonal Antibody (2H9)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA5-15922 targets MBP in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human MBP expressed in E. coli.
MA5-15922 detects MBP, which has a predicted molecular weight of approximately 33 kDa.

Target Information

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. MBP-related transcripts are also found in bone marrow and the immune system.
These transcripts arise from the long MBP gene (also called Golli-MBP) that contains three additional exons located upstream of the classic MBP exons.
Alternative splicing from the Golli and MBP transcription start sites produces two sets of MBP-related transcripts and gene products:

• Golli mRNAs contain three unique exons spliced in-frame to one or more MBP exons, encoding hybrid proteins with Golli and MBP sequences.
• Classic MBP transcripts contain only MBP exons and produce well-characterized myelin basic proteins.

This complex gene structure is conserved among species, suggesting that the MBP transcription unit is an integral part of the Golli transcription unit, important for gene function and regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.