Thermo Fisher Scientific PDGF-BB Polyclonal Antibody
PDGF-BB 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Human 및 Rat 반응성. 고순도 Affinity 정제 항체로, 안정적인 액상 형태로 제공되며 -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 140–241 of human PDGFB (NP_002599.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.58 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804792 |
Product Specific Information
- Positive Samples: SW480, MCF7, Mouse skeletal muscle
- Immunogen Sequence:
QCRPTQVQLR PVQVRKIEIV RKKPIFKKAT VTLEDHLACK CETVAAARPV TRSPGGSQEQ RAKTPQTRVT IRTVRVRRPP KGKHRKFKHT HDKTALKETL GA
Target Information
The protein encoded by this gene is a member of the platelet-derived growth factor (PDGF) family. Members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines.
This gene product can exist as a homodimer (PDGF-BB) or as a heterodimer with PDGF-alpha (PDGF-AB), connected by disulfide bonds.
Mutations in this gene are associated with meningioma, and chromosomal translocations involving this gene and COL1A1 are linked to dermatofibrosarcoma protuberans, leading to unregulated growth factor expression.
Two alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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