Thermo Fisher Scientific IQSEC1 Polyclonal Antibody
IQSEC1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 시료에 반응하며 IHC(P) 실험에 적합. 항원 친화 크로마토그래피로 정제된 액상형 제품으로, 장기 보관 시 -20°C에서 안정적. 연구용으로만 사용 가능.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human IQSEC1. Recombinant protein control fragment (Product #RP-96356). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2642771 |
Product Specific Information
- Immunogen sequence:
GSLKRQSAYE RSLGGQQGSP KHGPHSGAPK SLPREEPELR PRPPRPLDSH LAINGSANRQ SKSESDYSDG DNDSINSTSN S - Highest antigen sequence identity:
Mouse - 94%, Rat - 94%
Target Information
ADP ribosylation factors (Arfs) are small GTP-binding proteins involved in vesicular transport, where they nucleate the assembly of coat protein complexes at carrier vesicle formation sites.
IQSEC1 (GEP100/BRAG2) is a guanine nucleotide exchange protein for ARF6, belonging to the BRAG family, and includes one IQ domain, one PH domain, and one SEC7 domain.
As an activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin; its knockdown blocks tumor metastasis. IQSEC1 links EGFR signaling to ARF6 activation and may contribute to cancer metastasis and malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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