Thermo Fisher Scientific IQSEC1 Polyclonal Antibody
Human IQSEC1 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. 연구용으로 세포 신호전달 및 암 전이 관련 연구에 활용 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human IQSEC1. Recombinant protein control fragment (Product #RP-96357). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642770 |
Product Specific Information
- Immunogen sequence:
PSSETGTSLD SPSAYPQGPL VPGSSLSPDH YEHTSVGAYG LYSGPPGQQQ RTRRPKLQHS TSILRKQAE - Highest antigen sequence identity to the following orthologs:
Mouse – 91%, Rat – 91%
Target Information
ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation.
IQSEC1 (GEP100/BRAG2), a guanine nucleotide exchange protein for ARF6, belongs to the BRAG family and contains one IQ domain, one PH domain, and one SEC7 domain.
As a known activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin and its knockdown blocked tumour metastasis. IQSEC1 links EGFR signaling to ARF6 activation and may contribute to cancer metastasis and malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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