Thermo Fisher Scientific Gemin 3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunocytochemistry (ICC/IF)

1:10-1:100

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 25-280 of human DDX20 (NP_009135.4). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Gemin 3,uniProtId:Q9UHI6-1,ncbiNodeId:9606,antigenRange:25-280,antigenLength:824,antigenImageFileName:PA5-120950_Gemin_3_Q9UHI6-1_Rabbit.svg,antigenImageFileNamePDP:PA5-120950_Gemin_3_Q9UHI6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.04 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914522

Product Specific Information

Positive test controls include: MCF7, ES-2, 293T, HepG2, HeLa, Mouse spleen, Rat testis, Mouse ovary. The target is usually found in the following locations: Cytoplasm, Nucleus, gem.

Immunogen sequence: VQVPAPEPTP GPVRILRTAQ DLSSPRTRTG DVLLAEPADF ESLLLSRPVL EGLRAAGFER PSPVQLKAIP LGRCGLDLIV QAKSGTGKTC VFSTIALDSL VLENLSTQIL ILAPTREIAV QIHSVITAIG IKMEGLECHV FIGGTPLSQD KTRLKKCHIA VGSPGRIKQL IELDYLNPGS IRLFILDEAD KLLEEGSFQE QINWIYSSLP ASKQMLAVSA TYPEFLANAL TKYMRDPTFV RLNSSDPSLI GLKQYY

Target Information

Gemin 3 is a member of the DEAD box protein family which are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. DEAD box proteins such as Gemin 3 are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of DEAD box family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Gemin 3 has an ATPase activity and a component of the survival of motor neurons (SMN) complex. The Gemin 3 protein may play a catalytic role in the function of the SMN complex on RNPs. Diseases associated with Gemin 3 protein dysfunction include spinal muscular dystrophy and muscular atrophy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.