
Thermo Fisher Scientific EPS15R Polyclonal Antibody
Rabbit polyclonal antibody against human EPS15R protein. Validated for WB and IHC applications. Detects endogenous EPS15R involved in receptor-mediated endocytosis. Supplied unconjugated in PBS with glycerol and sodium azide, stored at -20°C.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:25–1:100 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to residues near the C-terminal of human epidermal growth factor receptor pathway substrate 15-like 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635792 |
Product Specific Information
The antibody detects endogenous levels of total EPS15R protein.
Target Information
EPS15R appears to be a constitutive component of clathrin-coated pits required for receptor-mediated endocytosis. It is involved in the endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Internalization of ITGB1 as DAB2-dependent cargo, but not TFR, seems to require association with DAB2. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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