Thermo Fisher Scientific Endothelin 3 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Endothelin 3. Validated for Western blot at 1:500–1:2,000 dilution. Affinity-purified with >95% purity. Supplied in liquid form, 1 mg/mL, PBS with 50% glycerol. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human Endothelin 3 (aa 1–238) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720394 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
The protein encoded by this gene belongs to the endothelin family, which includes endothelium-derived vasoactive peptides involved in various biological functions. The active form of this protein is a 21-amino-acid peptide processed from the precursor protein and acts as a ligand for endothelin receptor type B (EDNRB). This interaction is crucial for the development of neural crest-derived cell lineages such as melanocytes and enteric neurons. Mutations in this gene and in EDNRB are associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), both congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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