Thermo Fisher Scientific MEK2 N-Term Polyclonal Antibody, HRP

Thermo Fisher Scientific MEK2 N-Term Polyclonal Antibody, HRP

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Store vial at 4°C prior to restoration.
• For extended storage, aliquot and freeze at -20°C or below.
• Avoid cycles of freezing and thawing.
• Centrifuge if not clear after standing at room temperature.
• Stable for several weeks at 4°C as undiluted liquid.
• Dilute only prior to immediate use.

This HRP-conjugated affinity purified antibody is directed against human MEK2 protein.
Cross-reactivity is expected with human, mouse, and rat based on sequence identity of the peptide immunogen.
This antibody does not react with the MEK1 isoform.

Target Information

MAP2K2 (MEK2) is a dual specificity serine/threonine kinase that plays a critical role in mitogen growth factor signal transduction.
MEK2 (MAPKK2) activates ERK1/2 and MAPK enzymes by phosphorylating residues within the TEY motif in the activation loop.
MEK1 and MEK2 are activated by dual phosphorylation on serine 218 and 222.
Threonine 292 of MEK1 is phosphorylated by ERK2, serving as a negative feedback loop suppressing MEK1 activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.