Thermo Fisher Scientific ATF4 Monoclonal Antibody ([N360A/24), PE

Applications and Tested Dilution

Product Specifications

Additional Formats

• Unconjugated (MA5-27721)
• FITC (MA5-45648)
• PerCP (MA5-45649)
• Custom conjugation available upon request

Product Specific Information

• 86% identical to rat, 85% identical to mouse; <50% identity with ATF5
• 1 µg/mL of MA5-45650 detects ATF4 in 20 µg rat brain lysate by colorimetric immunoblot using Goat anti-mouse IgG:HRP
• Detects approximately 60 kDa; does not cross-react with ATF5
• Formerly sold as clone S360A-24

Target Information

The ATF4 gene encodes a transcription factor originally identified as a mammalian DNA-binding protein that interacts with a tax-responsive enhancer element in the LTR of HTLV-1. It is also known as cAMP-response element binding protein 2 (CREB-2).
ATF4 belongs to a family of DNA-binding proteins that includes AP-1, CREBs, and CREB-like proteins. These transcription factors share a leucine zipper domain involved in protein-protein interactions, adjacent to a basic DNA-binding domain.
Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 within a region containing a large inverted duplication.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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