Thermo Fisher Scientific Natalizumab Chimeric Recombinant Human Monoclonal Antibody (Natalizumab)

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

Assay-dependent

-

Inhibition Assays (IA)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Human / IgG4, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

Natalizumab

Immunogen

The RAMOS cell line, a non-EBV releasing cell line, injected into mice.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

0.02% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

Product Specific Information

This antibody binds to the alpha 4 binds subunit of alpha 4 Beta 1 (also known as very late antigen 4 [VLA-4] or CD49d-CD29) and alpha 4 Beta 7 integrin

Target Information

Natalizumab is a recombinant, humanized monoclonal antibody, binds to alpha4beta1-integrinand blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn`s disease. Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.