Thermo Fisher Scientific Natalizumab Chimeric Recombinant Human Monoclonal Antibody (Natalizumab)
Natalizumab은 인간화 재조합 단일클론 항체로, α4β1 인테그린과 결합하여 VCAM-1 상호작용을 차단합니다. 다발성 경화증 및 크론병 연구에 활용 가능하며, HEK293 세포에서 발현된 IgG4 항체입니다. 단백질 A로 정제되어 액상 형태로 제공됩니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Inhibition Assays (IA)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Human / IgG4, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Natalizumab |
| Immunogen | The RAMOS cell line, a non-EBV releasing cell line, injected into mice. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody binds to the alpha 4 subunit of alpha 4 beta 1 (also known as very late antigen 4 [VLA-4] or CD49d-CD29) and alpha 4 beta 7 integrin.
Target Information
Natalizumab is a recombinant, humanized monoclonal antibody that binds to alpha4beta1 integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). It can be used for the study of relapsing-remitting multiple sclerosis and Crohn’s disease. Natalizumab is the first targeted therapy that blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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