Thermo Fisher Scientific CD89 Chimeric Recombinant Rabbit Monoclonal Antibody (14A8 (14.1))
CD89 단백질의 세포외 도메인 2를 인식하는 재조합 토끼 단일클론 항체. 인간 시료에 반응하며 Flow Cytometry, ELISA, IP, 기능 분석에 사용 가능. HEK293 세포에서 발현, Protein A 정제, 1 mg/mL 농도. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Flow Cytometry (Flow) | 1:100 | |
| ELISA (ELISA) | Assay-dependent | |
| Immunoprecipitation (IP) | Assay-dependent | |
| Functional Assay (Functional) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 14A8 (14.1) |
| Immunogen | The original antibody was generated by immunizing HCO12 transgene-containing mice with recombinant soluble CD89 antigen. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody binds CD89 in the extracellular domain 2, outside the IgA-binding site.
Target Information
This gene encodes a receptor for the Fc region of IgA and belongs to the immunoglobulin gene superfamily. The receptor is a transmembrane glycoprotein expressed on myeloid lineage cells including neutrophils, monocytes, macrophages, and eosinophils. It mediates immune responses to pathogens through interaction with IgA-opsonized targets, triggering processes such as phagocytosis, antibody-dependent cell-mediated cytotoxicity, and release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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