Thermo Fisher Scientific SIAH1/SIAH2 Polyclonal Antibody
SIAH1/SIAH2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합하며 인간, 생쥐, 랫드 반응성. 항원 친화 크로마토그래피로 정제, 1 mg/mL 농도, PBS buffer 및 sodium azide 포함.
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Thermo Fisher Scientific SIAH1/SIAH2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 178–229 of human Siah-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 15 mM sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2553449 |
Product Specific Information
- Detects endogenous protein at a molecular weight of 40 kDa.
- Purity >95% by SDS-PAGE.
Target Information
SIAH, the human homologue of the Drosophila seven in absentia (sina) gene, is a tumor suppressor protein expressed in intestinal epithelium and activated during apoptosis.
Human SIAH proteins are produced as two distinct gene products, SIAH-1 and SIAH-2, sharing a highly conserved C-terminal sequence but differing in their N-terminal regions.
SIAH-1 (32 kDa) contains:
- N-terminal RING-finger domain (required for proteolysis)
- Cysteine-rich C-terminal domain (regulates oligomerization and target binding)
As a tumor suppressor, SIAH-1 binds DCC (deleted in colorectal cancer) and regulates its degradation via the ubiquitin-proteasome pathway.
It also binds Bag-1, a Bcl-2 related protein, inhibiting cell growth.
Most SIAH-1 localizes to the nucleus, with a small fraction in the cytoplasm, suggesting interactions with nuclear matrix proteins and DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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