Thermo Fisher Scientific LDLR Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
TVEIVTMSHQ ALGDVAGRGN EKKPSSVRAL SIVLPIVLLV FLCLGVFLLW KNWRLKNINS INFDNPVYQK TTEDEVHICH NQDGYSYPSR QMVSLEDDVA

Positive Samples: HeLa, Jurkat, LO2, HL-60, NIH/3T3
Cellular Location: Cell membrane, Cell surface, Early endosome, Endomembrane system, Golgi apparatus, Late endosome, Lysosome, Membrane, Single-pass type I membrane protein, clathrin-coated pit

Target Information

The low-density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL binds to the receptor on the cell membrane and is internalized into lysosomes, where it is degraded to release cholesterol. This cholesterol regulates HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, and stimulates cholesterol ester formation. Mutations in the LDL-R gene cause familial hypercholesterolemia, an autosomal dominant disorder. LDL-R also functions as an entry factor for the Hepatitis C virus along with SCARB1, CLDN1, and CD81. At least three isoforms of LDL-R are known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.