Thermo Fisher Scientific LDLR Polyclonal Antibody
Thermo Fisher Scientific의 LDLR Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하며 Western blot, IHC, ICC, ELISA 등에 사용됩니다. Rabbit IgG 폴리클로날 항체로, 세포막 및 엔도좀 단백질 검출에 적합합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 761–860 of human LDL Receptor (LDLR) (NP_000518.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.05 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805946 |
Product Specific Information
Immunogen sequence:
TVEIVTMSHQ ALGDVAGRGN EKKPSSVRAL SIVLPIVLLV FLCLGVFLLW KNWRLKNINS INFDNPVYQK TTEDEVHICH NQDGYSYPSR QMVSLEDDVA
Positive Samples: HeLa, Jurkat, LO2, HL-60, NIH/3T3
Cellular Location: Cell membrane, Cell surface, Early endosome, Endomembrane system, Golgi apparatus, Late endosome, Lysosome, Membrane, Single-pass type I membrane protein, clathrin-coated pit
Target Information
The low-density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL binds to the receptor on the cell membrane and is internalized into lysosomes, where it is degraded to release cholesterol. This cholesterol regulates HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, and stimulates cholesterol ester formation. Mutations in the LDL-R gene cause familial hypercholesterolemia, an autosomal dominant disorder. LDL-R also functions as an entry factor for the Hepatitis C virus along with SCARB1, CLDN1, and CD81. At least three isoforms of LDL-R are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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