Thermo Fisher Scientific TCF7L2 Monoclonal Antibody (K.120.3)
TCF7L2 단백질을 인식하는 Mouse monoclonal antibody (Clone K.120.3). Western blot 및 Immunoprecipitation에 적합하며, 인간 시료에 반응합니다. Affinity chromatography로 정제된 액상 시약으로, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunoprecipitation (IP) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | K.120.3 |
| Immunogen | Synthetic peptide corresponding to residues surrounding Glu81 of human TCF4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 494 µg/mL |
| Purification | Affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_10983701 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
TCF7L2 (also known as TCF4) is a high mobility group (HMG) box-containing transcription factor involved in the Wnt signaling pathway. It regulates pro-glucagon gene expression, influencing glucose homeostasis and GLP-1 production. Genetic variants of TCF7L2 are associated with type 2 diabetes and play roles in beta-cell survival and function. Different splicing isoforms are expressed during cancer progression, and TCF7L2 is essential for maintaining small intestine crypt stem cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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