Thermo Fisher Scientific TAB2 Monoclonal Antibody (G.188.0)
TAB2 단백질을 인식하는 Rabbit monoclonal antibody(G.188.0)로, Western blot 및 Immunoprecipitation에 적합합니다. Human, Mouse, Rat 등 다양한 종에 반응하며, 액상 형태로 제공됩니다. 친화 크로마토그래피로 정제되었으며, -20°C에서 보관합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TAB2 Monoclonal Antibody (G.188.0)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunoprecipitation (IP) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | G.188.0 |
| Immunogen | Synthetic peptide corresponding to residues surrounding Leu330 of human TAB2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_10986190 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
TAB2 is an activator of MAP3K7/TAK1, required for IL-1 induced activation of NF-kappaB and MAPK8/JNK. It forms a kinase complex with TRAF6, MAP3K7, and TAB1, serving as an adaptor linking MAP3K7 and TRAF6. TAB2, TAB1, and MAP3K7 also participate in TNFSF11/RANKL-induced signaling through TNFRSF11A/RANK, which may regulate osteoclast development and function.
Recent studies show TAB2 and TAB3 interact with autophagy mediator Beclin-1; upon autophagy induction, they dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibits autophagy, while depletion triggers it, suggesting they act as control points for autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.