Thermo Fisher Scientific DFNA5 Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DFNA5 (-, 1 a.a. approximately 295 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DFNA5,uniProtId:O60443-1,ncbiNodeId:9606,antigenRange:1-496,antigenLength:496,antigenImageFileName:H00001687-B01P_DFNA5_O60443-1_House_mouse.svg,antigenImageFileNamePDP:H00001687-B01P_DFNA5_O60443-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MQKCVISEHM QVEEKCGGIV GIQTKTVQVS ATEDGNVTKD SNVVLEIPAA TTIAYGVIEL YVKLDGQFEF CLLRGKQGGF ENKKRIDPVY LDPLVFREFA FIDMPDAAHG ISSQDGPLSV LKQATLLLER NFHPFAELPE PQQTALSDIF QAVLFDDELL MVLEPVCDDL VSGLSPTVAV LGELKPRQQQ DLVAFLQLVG CSLQGGCPGP EDAGSKQLFM TAYFLVSALA EMPDSAAALL GTCCKLQIIP TLCHLLRALS DDGVSDLEDP TLTPLKDTER FGIVQRLFAS ADISL

Target Information

DFNA5 (deafness, autosomal dominant 5), also known as ICERE-1, is a 496 amino acid protein that is expressed in cochlea tissue, as well as in placenta, brain, heart, liver, lung and pancreas as two alternatively spliced isoforms, designated short and long. Defects in the gene encoding DFNA5 are the cause of non-syndromic sensorineural deafness autosomal dominant type 5 (DFNA5), a form of sensorineural hearing loss that results from damage to one of various structures that receive sound information in the brain. The gene encoding DFNA5 maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.