Thermo Fisher Scientific DFNA5 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MQKCVISEHM QVEEKCGGIV GIQTKTVQVS ATEDGNVTKD SNVVLEIPAA TTIAYGVIEL YVKLDGQFEF CLLRGKQGGF ENKKRIDPVY LDPLVFREFA FIDMPDAAHG ISSQDGPLSV LKQATLLLER NFHPFAELPE PQQTALSDIF QAVLFDDELL MVLEPVCDDL VSGLSPTVAV LGELKPRQQQ DLVAFLQLVG CSLQGGCPGP EDAGSKQLFM TAYFLVSALA EMPDSAAALL GTCCKLQIIP TLCHLLRALS DDGVSDLEDP TLTPLKDTER FGIVQRLFAS ADISL

Target Information

DFNA5 (deafness, autosomal dominant 5), also known as ICERE-1, is a 496 amino acid protein expressed in cochlea tissue as well as in placenta, brain, heart, liver, lung, and pancreas. It exists in two alternatively spliced isoforms (short and long).
Defects in DFNA5 cause non-syndromic sensorineural deafness type 5 (DFNA5), a form of hearing loss due to damage in auditory pathways. The DFNA5 gene is located on human chromosome 7, which contains over 1,000 genes (~5% of the human genome). Mutations in genes on chromosome 7 are associated with disorders such as Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia, and Shwachman-Diamond syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.