Thermo Fisher Scientific TCR V alpha 3.2 Monoclonal Antibody (RR3-16), FITC, eBioscience
마우스 TCR V alpha 3.2 체인을 인식하는 RR3-16 단클론 항체로, FITC 형광 표지되어 있습니다. Flow cytometry 분석에 최적화되었으며, 0.125 µg/test로 사용 가능합니다. 488 nm Blue Laser 기반 분석에 적합하며, 4°C 암저장 조건에서 안정적입니다.
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Thermo Fisher Scientific TCR V alpha 3.2 Monoclonal Antibody (RR3-16), FITC
Applications
- Flow Cytometry (Flow)
Tested Dilution: 0.125 µg/test
Publications: View 5 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2b, kappa |
| Recommended Isotype Control | Rat IgG2b kappa Isotype Control (eB149/10H5), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RR3-16 |
| Conjugate | FITC |
| Excitation/Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572504 |
Additional Formats
Product Specific Information
This RR3-16 monoclonal antibody reacts with the mouse T cell receptor (TCR) V alpha 3.2 chain. TCR specificity is determined by Va, Ja, Vb, Db, and Jb gene rearrangement. The RR3-16 antibody recognizes the V alpha 3.2 chain on T cells from mouse strains bearing the b (e.g., C57BL/6) or c haplotype (e.g., SJL, SWR, NOD) in the Tcra gene complex.
The V alpha 3.2 chain is absent in mice with the a (e.g., Balb/c, AKR, C3H) and d (e.g., DBA/1, DBA/2) haplotypes.
Studies show that the V alpha 3.2 TCR is more highly expressed on CD8+ T cells.
Applications Reported: Flow cytometric analysis
Applications Tested: Tested by flow cytometric analysis of mouse splenocytes (≤ 0.125 µg/test).
A test is defined as the amount of antibody that stains a cell sample in 100 µL volume. Recommended titration for optimal performance.
Excitation: 488 nm
Emission: 520 nm
Laser: Blue Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
T cell receptors (TCRs) discriminate foreign from self-peptides presented by MHC class II molecules, essential for adaptive immune response.
TCR recognition of self-peptides is linked to autoimmune diseases, and mutant self-peptides are associated with tumors.
Superantigen engagement of TCRs can cause toxic shock syndrome.
Autoantibodies to V beta segments have been found in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), potentially regulating TH1-mediated inflammation.
Most human T cells express TCR alpha-beta and either CD4 or CD8 (single positive). A small subset lacks both (double negative), which increases in autoimmune and immunodeficiency disorders.
Gamma-delta T cells, primarily in epithelia, exhibit less diversity and distinct antigen recognition, with antitumor and immunoregulatory roles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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