Thermo Fisher Scientific AXIN1 Polyclonal Antibody
AXIN1 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체로, 인간에서 반응하며 WB 및 IHC(P) 실험에 적합합니다. WNT 신호 경로 연구 및 종양 억제 관련 연구에 활용됩니다. 고순도 액상 형태로 안정적인 저장이 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3–5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (FEEKIIGKVEKVD) corresponding to the C-terminus amino acids of AXIN1 (aa 850–862) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10980981 |
Product Specific Information
This antibody is predicted to react with bovine, canine, mouse, and rat based on sequence homology.
Tested in Peptide ELISA: antibody detection limit dilution 128,000.
Target Information
AXIN1 is a cytoplasmic protein containing a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain. It functions as a negative regulator of the WNT signaling pathway that controls embryonic axis formation. AXIN1 interacts with APC, beta-catenin, and glycogen synthase kinase 3 beta, forming a complex that regulates beta-catenin stabilization. Mutations in AXIN1 are associated with various carcinomas, suggesting a tumor suppressor role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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