Thermo Fisher Scientific Nicastrin Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 Nicastrin 폴리클로날 항체로, WB, IHC, ICC에 사용 가능. 항원 친화 크로마토그래피로 정제된 Rabbit IgG. PBS 버퍼에 0.02% sodium azide 포함, 2–8°C 보관. 알츠하이머 연구 및 감마-시크리타제 복합체 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–1 µg/mL | - |
| Immunohistochemistry (IHC) | 2.5 µg/mL | 1 publication |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide from near the center of human Nicastrin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 2–8°C up to 3 months; long-term at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155438 |
Product Specific Information
- Suggested positive control: human brain tissue lysate
- PA5-20304 can be used with blocking peptide PEP-0429
Target Information
NCSTN (Nicastrin) encodes a type I transmembrane glycoprotein, an integral component of the gamma-secretase complex. This protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may serve as a stabilizing cofactor for gamma-secretase complex assembly. Cleavage of beta-amyloid precursor protein produces amyloid beta peptide, the main component of neuritic plaques associated with Alzheimer’s disease. Although its exact role in Alzheimer’s disease remains uncertain, mutations in NCSTN are linked to familial acne inversa. A pseudogene is present on chromosome 21.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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