Thermo Fisher Scientific Nicastrin Polyclonal Antibody
Nicastrin 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 인간, 생쥐, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 제품으로, 1 mg/mL 농도. 알츠하이머 연구 등 감마-시크리타제 복합체 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid peptide from near the carboxy terminus of human Nicastrin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152451 |
Product Specific Information
- A suggested positive control is mouse brain tissue lysate.
- PA5-20303 can be used with blocking peptide PEP-0428.
Target Information
NCSTN (Nicastrin) encodes a type I transmembrane glycoprotein that is part of the gamma-secretase complex. This protein is involved in the cleavage of integral membrane proteins, including Notch receptors and beta-amyloid precursor protein. It may act as a stabilizing cofactor required for gamma-secretase complex assembly.
Cleavage of beta-amyloid precursor protein produces amyloid beta peptide, the main component of neuritic plaques characteristic of Alzheimer’s disease, though the exact role of Nicastrin in Alzheimer’s pathology remains uncertain.
Mutations in NCSTN are associated with familial acne inversa. A pseudogene of NCSTN is located on chromosome 21.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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