Thermo Fisher Scientific c-Cbl Polyclonal Antibody
Thermo Fisher Scientific의 c-Cbl Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며 Western blot과 IHC에 적합합니다. 항원 친화 크로마토그래피로 정제된 액상 항체로, Daudi cell lysate를 양성 대조군으로 사용할 수 있습니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunohistochemistry (IHC) | 20 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide from near the carboxy terminus of human c-Cbl |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155809 |
Product Specific Information
A suggested positive control is Daudi cell lysate.
PA5-20299 can be used with blocking peptide PEP-0423.
Target Information
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation.
Cbl-c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells, whereas other Cbl proteins are ubiquitously expressed.
Cbl-c, like other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation.
Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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