Thermo Fisher Scientific Phospho-ATR (Thr1989) Recombinant Rabbit Monoclonal Antibody (PS01-18)
Recombinant rabbit monoclonal antibody targeting phospho-ATR (Thr1989). Validated for WB and ICC/IF. High specificity for human ATR; ideal for DNA damage and cell cycle checkpoint research. Supplied as liquid, 1 mg/mL, Protein A purified.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PS01-18 |
| Immunogen | Synthetic peptide surrounding Thr1989 of human ATR/2644 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3092903 |
Product Specific Information
- Positive control: HeLa cell lysate, HeLa treated with Hydroxyurea cell lysate (4 mM for 20 hours)
- Predicted band size: 301 kDa
- Subcellular Location: Chromosome, Nucleus
Target Information
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. It phosphorylates and activates several proteins involved in inhibiting DNA replication and mitosis, and promotes DNA repair, recombination, and apoptosis. This protein is important for fragile site stability and centrosome duplication. Defects in this gene cause Seckel syndrome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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