Thermo Fisher Scientific c-Myc Recombinant Rabbit Monoclonal Antibody (PS00-11)
Thermo Fisher Scientific의 c-Myc Recombinant Rabbit Monoclonal Antibody (PS00-11)은 인간 c-Myc 단백질을 인식하는 고특이성 항체로, WB 및 IHC(P) 실험에 최적화되어 있습니다. 단백질 A로 정제된 액상 형태이며, 세포 증식 및 종양 관련 연구에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PS00-11 |
| Immunogen | Synthetic peptide aa 390–454 of human c-Myc |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3092986 |
Product Specific Information
- Positive control: Jurkat, Daudi, K562, HL-60 cell lysates; human B lymphocytoma tissue; human colon and colon carcinoma tissue
- Predicted band size: 49 kDa
- Subcellular Location: Nucleoplasm, nucleolus
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumors and plays critical roles in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is associated with cell proliferation and cycle regulation.
c-Myc is essential for vasculogenesis and angiogenesis in tumor development. Deregulated expression of c-Myc can induce apoptosis and contribute to oncogenesis. Amplification of the c-Myc gene has been found in lung, breast, and colon carcinomas, while N-Myc amplification is common in neuroblastomas.
Translocation of the c-Myc locus to immunoglobulin loci (chromosomes 14, 2, or 22) is characteristic of Burkitt’s lymphoma and other B-cell proliferative disorders. Aberrant expression of c-Myc occurs across multiple tumor types, including colorectal, gastric, hepatic, ovarian, and hematopoietic neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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