Thermo Fisher Scientific ARID1A Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive test controls include: C2C12, C6, Rat lung
• Immunogen sequence:
  LLGFLEDSLA ATQFQQSQAS LLHMQNPPFE PTSVDMMRRA ARALLALAKV DENHSEFTLY ESRLLDISVS PLMNSLVSQV ICDVLFLIGQ S

Target Information

This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes.
The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin.
It possesses at least two conserved domains that could be important for its function:

1. A DNA-binding domain that specifically binds an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus.
2. A C-terminal domain that can stimulate glucocorticoid receptor-dependent transcriptional activation.

It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions.
Two transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.