Thermo Fisher Scientific Caspase 1 Polyclonal Antibody
Caspase-1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(Paraffin)에서 검증됨. 세포질 내 Caspase-1 검출에 적합하며, 염증성 사이토카인 활성 연구에 활용 가능. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 – 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 – 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 200–300 of human Cleaved Caspase-1 (NP_150634.1). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.88 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914226 |
Product Specific Information
Positive test controls include: HeLa, THP-1, Mouse lung.
The target is usually found in the following locations: Cytoplasm.
Target Information
Caspases are a family of cysteine proteases divided into apoptotic and inflammatory subfamilies. Unlike apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with immune responses to microbial pathogens. Members include caspase-1, -4, -5, and -12, which can activate proinflammatory cytokines such as IL-1β and IL-18.
Caspase-1 was initially identified as an IL-1β-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3, whose overexpression can induce apoptosis in fibroblasts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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