Thermo Fisher Scientific Phospho-LKB1 (Ser428) Polyclonal Antibody
LKB1 단백질의 Ser428 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(P)에서 사용 가능. Human, Mouse, Rat에 반응하며, 고순도의 항원 친화 크로마토그래피 정제 제품. 연구용으로 4°C 또는 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human LKB1 around the phosphorylation site of Serine 428 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2553784 |
Product Specific Information
- Detects endogenous LKB1 protein at approximately 54 kDa.
- Purity: >95% by SDS-PAGE.
Target Information
LKB1 (also known as STK11, Serine/threonine-protein kinase STK11) is a tumor suppressor belonging to the serine/threonine kinase family.
It physically associates with p53 and regulates specific p53-dependent apoptosis pathways.
LKB1 is localized in both the cytoplasm and nucleus, and translocates to mitochondria during apoptosis.
It acts as a master upstream kinase regulating AMPK and AMPK-related kinases.
Mutations in the LKB1 gene are associated with Peutz-Jeghers syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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