Thermo Fisher Scientific FOXO4 Polyclonal Antibody
FOXO4 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB, ICC/IF, IP 등 다양한 응용에 사용 가능. 인간 시료 반응성, 항원 친화 크로마토그래피 정제, 액상 형태로 제공. 연구용으로만 사용.
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Thermo Fisher Scientific FOXO4 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to C-terminal residues 451–466 of human AFX / FOXO4, with an N-terminal added lysine |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2294293 |
Product Specific Information
- Recommended positive control: Cos-7 cells
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome. It is also known as AFX1 or MLLT7 (Myeloid/Lymphoid or Mixed-Lineage Leukemia, Trithorax Homolog, Translocated To, 7).
FOXO4 belongs to the O class of forkhead/winged helix family of transcription factors along with FOXO1, FOXO3, and FOXO6.
FOXO4 is abundantly expressed in skeletal muscle and adipose tissue. It binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1.
Activation of Akt leads to phosphorylation of FOXO4 on specific Ser/Thr residues, mediating binding to 14-3-3 and promoting nuclear export.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA1-25421_FOXO4_P98177-1_Rabbit.svg, PA1-25421_FOXO4_P98177-1_Rabbit_PDP.jpeg)
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