Thermo Fisher Scientific TRHR Polyclonal Antibody

Applications

Tested Application

• Immunohistochemistry (Paraffin) (IHC (P)): 20 µg/mL

Product Specifications

Product Specific Information

• Percent identity with other species by BLAST analysis:
  Human, Gorilla, Gibbon, Monkey, Sheep, Dog, Elephant, Panda, Horse, Pig (100%);
  Marmoset, Mouse, Rat, Bovine, Hamster, Opossum, Turkey, Chicken, Lizard, Xenopus (94%);
  Stickleback (88%); Rabbit, Zebrafish (81%).
• For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer.
• After incubation with the primary antibody, slides were treated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

TRH-R is a 398 amino acid integral membrane protein with six transmembrane domains and belongs to the G-protein coupled receptor 1 family.
It acts as a receptor for the signaling hormone TRH and activates the inositol phospholipid-calcium-protein kinase C transduction pathway upon TRH binding.
TRH-R functions as a neurotransmitter and neuro regulator, controlling receptor dimerization and hormone-induced receptor trafficking.
It is widely expressed in the thyrotroph cells of the anterior pituitary.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.