Thermo Fisher Scientific TNIK Polyclonal Antibody
Rabbit polyclonal antibody against TNIK, reactive with human and non-human primate samples. Suitable for IHC(P) and ELISA. Validated using antigen affinity purification. Supplied in PBS with 0.1% sodium azide. For research use only.
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- PA533086
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 10 µg/mL
- Recommended: Use heat-induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 19 amino acid peptide from internal region of human TNIK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550545 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Gorilla, Gibbon, Monkey, Marmoset: 100%
- Mouse, Rat, Bovine, Dog, Bat, Elephant, Panda, Horse, Rabbit, Opossum, Chicken, Lizard, Xenopus: 95%
- Platypus: 89%
Target Information
TNIK (TRAF2 and NCK Interacting Kinase) is characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function. TNIK is mainly expressed in brain, heart, and spleen, and acts as a specific effector of RAP2, regulating the actin cytoskeleton.
It is autophosphorylated in a manner dependent upon Lys54 in the ATP-binding pocket of its kinase domain and plays a major role in cytoskeleton regulation. TNIK also phosphorylates gelsolin, an actin-severing protein, in vitro, suggesting its function in cytoskeletal regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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