Thermo Fisher Scientific TrkB Monoclonal Antibody (J.977.7)
TrkB 단백질을 인식하는 Rabbit monoclonal antibody(J.977.7)로, Western blot에 최적화되어 있습니다. Human, Mouse, Rat 시료에 반응하며 TrkA와 교차 반응하지 않습니다. 액상 형태, 10 µg/mL 농도, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | J.977.7 |
| Immunogen | Synthetic peptide surrounding Pro50 of human TrkB |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 10 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10983528 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with TrkA.
Target Information
NTRK2 (TRKB) belongs to the neurotrophic factor family, which is central to the development and maintenance of the mammalian nervous system. NTRK2 acts as the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses.
TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway, leading to cell differentiation. It is expressed primarily in the central and peripheral nervous systems. BDNF and NT-3 can induce tyrosine phosphorylation of TrkB, with BDNF eliciting a stronger response. Mutations in the TrkB gene have been linked to obesity and mood disorders. Alternative splice variants encoding different isoforms have also been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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