Thermo Fisher Scientific TrkB Monoclonal Antibody (J.977.7)

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000
• View 2 publications

Product Specifications

Product Specific Information

• It is not recommended to aliquot this antibody.
• This antibody is not cross-reactive with TrkA.

Target Information

NTRK2 (TRKB) belongs to the neurotrophic factor family, which is central to the development and maintenance of the mammalian nervous system. NTRK2 acts as the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses.

TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway, leading to cell differentiation. It is expressed primarily in the central and peripheral nervous systems. BDNF and NT-3 can induce tyrosine phosphorylation of TrkB, with BDNF eliciting a stronger response. Mutations in the TrkB gene have been linked to obesity and mood disorders. Alternative splice variants encoding different isoforms have also been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.