Thermo Fisher Scientific KRAS Monoclonal Antibody (OTI6A6), TrueMAB
KRAS 단백질을 인식하는 마우스 단클론 항체로 Western blot에 최적화되어 있습니다. 정제된 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능합니다. 인간 KRAS 단백질에 특이적으로 반응하며, 연구용으로 적합합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6A6 |
| Immunogen | Full length human recombinant protein of human KRAS produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
K-RAS (GTPase KRas) belongs to the Ras oncogene family, which binds GDP/GTP and possesses intrinsic GTPase activity.
It regulates cell proliferation and contributes to oncogenic processes by inducing transcriptional silencing of tumor suppressor genes in colorectal cancer cells in a ZNF304-dependent manner.
Mutations in this gene are associated with acute myelogenous leukemia, juvenile myelomonocytic leukemia, Noonan syndrome, gastric cancer, and cardiofaciocutaneous syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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