Thermo Fisher Scientific Neuropilin 1 Monoclonal Antibody (M534)
Neuropilin-1 단백질 검출용 마우스 단클론 항체(M534). Western blot, IHC(F), ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. Protein G 정제, 1 mg/mL 농도, PBS/BSA/glycerol 저장. VEGF 및 semaphorin 경로 연구에 적합.
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Thermo Fisher Scientific Neuropilin 1 Monoclonal Antibody (M534)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:250 |
| Immunocytochemistry (ICC/IF) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M534 |
| Immunogen | Clone M534 was generated from a neuropilin-1 synthetic peptide (coupled to carrier protein) corresponding to amino acids within the a1 CUB domain of human neuropilin-1. This sequence is highly conserved in rat and mouse neuropilin-1, and has low homology to neuropilin-2. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942705 |
Product Specific Information
The antibody detects a 130 kDa* protein corresponding to the apparent molecular mass of neuropilin-1 on SDS-PAGE immunoblots of human recombinant neuropilin-1 and in human PC3 cells.
Target Information
Neuropilin 1 is a 923 amino acid membrane-bound coreceptor belonging to the neuropilin family, containing two CUB domains, two F5/8 type C domains, and a MAM domain.
It forms a heterodimer with NRP2 (Neuropilin 2) and binds to plexin (PLXNB1) to form semaphorin receptors.
Predominantly expressed in the nervous system, Neuropilin 1 is involved in:
- Cardiovascular system development
- Angiogenesis
- Axon guidance and neuronal circuit formation
- Cell survival and migration
- Organogenesis outside the nervous system
This receptor functions as a receptor for semaphorins and vascular endothelial growth factor (VEGF) and regulates VEGF-induced angiogenesis.
Neuropilin 1 may also be implicated in aggressive prostate carcinoma and breast cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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