ELK Biotechnology Mucin 1 (phospho Tyr1243) rabbit pAb
Mucin 1 (phospho Tyr1243) rabbit pAb는 인산화된 MUC1 단백질을 인식하는 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간 및 생쥐 시료에 반응하며, 세포막 및 핵 내 위치 연구에 활용됩니다. -20°C에서 1년 보관 가능합니다.
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Mucin 1 (phospho Tyr1243) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Mucin 1 (phospho Tyr1243) rabbit pAb |
| Alternative Names | MUC1; PUM; Mucin-1; MUC-1; Breast carcinoma-associated antigen DF3; Carcinoma-associated mucin; Episialin; H23AG; Krebs von den Lungen-6; KL-6; PEMT; Peanut-reactive urinary mucin; PUM; Polymorphic epithelial mucin; PEM; Tumor-associated ep |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | IHC: 1/100–1/300; ELISA: 1/20000; Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human CD227/Mucin 1 around the phosphorylation site of Tyr1243 (AA range: 1204–1253) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 4582 |
| Human Swiss-Prot No. | P15941 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Apical cell membrane; Single-pass type I membrane protein. Located in the apical domain of polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Found in microvilli and tips of filopodial protrusions. Isoform 5, Y, and 9 are secreted forms. Mucin-1 subunit beta localizes to cell membrane, cytoplasm, and nucleus. Upon EGF or PDGFRB stimulation, translocates to the nucleus via CTNNB1 interaction, enhanced by phosphorylation. Colocalizes with JUP/gamma-catenin in the nucleus upon HRG stimulation. |
Background
This gene encodes a membrane-bound protein belonging to the mucin family. Mucins are O-glycosylated proteins essential for forming protective mucous barriers on epithelial surfaces and play roles in intracellular signaling. MUC1 is expressed on the apical surface of epithelial cells in tissues such as lung, breast, stomach, and pancreas. The protein undergoes proteolytic cleavage into alpha and beta subunits forming a heterodimeric complex. The N-terminal alpha subunit functions in cell adhesion, while the C-terminal beta subunit is involved in cell signaling. Overexpression, mislocalization, and altered glycosylation of MUC1 are associated with carcinomas. The gene contains a highly polymorphic VNTR domain, and alternative splicing results in multiple transcript variants.
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