ELK Biotechnology Tau (phospho Ser673) rabbit pAb

Tau (phospho Ser673) rabbit pAb

제품 개요

Tau 단백질의 Ser673 인산화 부위를 특이적으로 인식하는 rabbit polyclonal antibody입니다. 신경세포 내 미세소관 결합 단백질 Tau의 발현 및 인산화 상태를 분석하는 데 사용됩니다.

제품 정보

세포 내 위치

Cytoplasm, cytosol. Cell membrane; peripheral membrane protein; cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Secreted.
Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components (PubMed:10747907).
Can be secreted; secretion depends on protein unfolding and is facilitated by the cargo receptor TMED10, resulting in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059).

Background

This gene encodes the microtubule-associated protein tau (MAPT), whose transcript undergoes complex, regulated alternative splicing, producing several mRNA species. MAPT transcripts are differentially expressed in the nervous system depending on neuronal maturation stage and type.
MAPT gene mutations are associated with neurodegenerative disorders such as Alzheimer’s disease, Pick’s disease, frontotemporal dementia, cortico-basal degeneration, and progressive supranuclear palsy.
[provided by RefSeq, Jul 2008]