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ELK Biotechnology AIRE-1 (phospho Ser156) rabbit pAb
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AIRE 단백질의 Ser156 인산화 부위를 인식하는 rabbit polyclonal antibody로, WB 및 ELISA에 적합합니다. 인간, 랫드, 마우스 시료에 반응하며, 핵 및 세포질에서 발현되는 AIRE 단백질 연구에 유용합니다.
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- pk
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ELK Biotechnology ES5771-100UL AIRE-1 (phospho Ser156) rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES5771-50UL AIRE-1 (phospho Ser156) rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology AIRE-1 (phospho Ser156) rabbit pAb
제품명
AIRE-1 (phospho Ser156) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | AIRE; APECED; Autoimmune regulator; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; APECED protein |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human AIRE around the phosphorylation site of Ser156 (AA range: 126–175) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kD |
| Gene ID (Human) | 326 |
| Human Swiss-Prot No. | O43918 |
| Cellular Localization | Nucleus, Cytoplasm. Predominantly nuclear but also cytoplasmic (PubMed:11274163, PubMed:14974083). Found in nuclear body-like structures (dots) and in a filamentous vimentin-like pattern (PubMed:11274163, PubMed:14974083, PubMed:26084028). Associated with tubular structures (PubMed:11274163, PubMed:14974083). |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).
[provided by RefSeq, Jun 2012]
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