Thermo Fisher Scientific Bcl-2 (Apoptosis and Follicular Lymphoma Marker) Monoclonal Antibody (124)
Bcl-2 단백질을 인식하는 mouse monoclonal antibody로, apoptosis 및 follicular lymphoma 연구에 활용. Western blot, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 사용 가능. Human 시료에 반응하며, preservative-free PBS 용액 형태로 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 124 |
| Immunogen | Synthetic peptide corresponding to aa41–54 (GAAPAPGIFSSQPG-Cys) of human Bcl-2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Does not react with Mouse, Rat, Others-not known.
Target Information
BCL-2 is a key regulator of apoptosis that can either inhibit or promote cell death. Members of the BCL-2 family interact through dimerization to modulate apoptosis. For example, Bag1 forms a heterodimer with BCL-2, enhancing its anti-apoptotic effect. Bax and Bak are crucial for cytochrome c release from mitochondria, initiating apoptosis. Overexpression or translocation of BCL-2, such as to the Ig heavy chain locus, is associated with follicular lymphoma. High expression of BCL-2 alpha protein is observed in neoplastic germinal centers, while normal or hyperplastic centers are negative. Two transcript variants exist, differing at their C-terminal ends, and BCL-2 overexpression has been linked to cancers including B-cell lymphoma and prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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