Thermo Fisher Scientific Crystallin Alpha B Monoclonal Antibody (CRYAB/4663)
Crystallin Alpha B 단백질을 인식하는 Mouse Monoclonal Antibody로, 인간 및 랫트 시료에 반응합니다. IHC(P), IHC(PFA), Peptide Array 등 다양한 응용에 사용 가능하며, Protein A/G로 정제된 액상 형태입니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CRYAB/4663 |
| Immunogen | Recombinant human full-length CRYAB protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens.
The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of two primary gene products—alpha-A and alpha-B. There are at least five different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least five gamma-crystallins identified in bovine and rat lens.
Alpha-crystallin comprises about 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone-like manner by preventing the formation of aggregates that may lead to cataract formation. It is believed that phosphorylated states of alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintenance.
Alpha-B crystallin has been linked to Alexander’s disease, where it accumulates in brain cells of those afflicted.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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