Thermo Fisher Scientific Crystallin Alpha B Monoclonal Antibody (CRYAB/4665)
CRYAB 단백질을 인식하는 Mouse monoclonal 항체로, IHC(P), IHC(PFA), Peptide Array에 사용 가능. 인간 시료에 반응하며, Protein A/G 정제 및 PBS 완충액에 보관. 렌즈 단백질 연구 및 스트레스 반응 관련 단백질 분석에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CRYAB/4665 |
| Immunogen | Recombinant human full-length CRYAB protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Lens proteins consist almost entirely of crystallins (about 95%), which are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to maintain the proper refractive index.
The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin, the largest, is composed of two primary gene products—alpha-A and alpha-B.
Alpha-crystallin comprises about 40% of total lens protein and functions as a molecular chaperone, preventing aggregation that could lead to cataract formation.
Phosphorylated states of alpha-crystallin may occur in response to cellular stress, playing roles in structural control and protein maintenance.
Alpha-B crystallin has been linked to Alexander’s disease, where it accumulates in brain cells of affected individuals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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