Thermo Fisher Scientific Crystallin Alpha B Monoclonal Antibody (CRYAB/4661)
인간 CRYAB 단백질을 인식하는 mouse monoclonal antibody로, IHC(P), IHC(PFA), Peptide Array 등 다양한 응용에 사용 가능. Protein A/G로 정제된 액상 형태이며 4°C에서 보관. 렌즈 단백질 연구 및 스트레스 반응 관련 단백질 분석에 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CRYAB/4661 |
| Immunogen | Recombinant human full-length CRYAB protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens.
The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma.
Alpha-crystallin is the largest and composed of two primary gene products: alpha-A and alpha-B. Beta-crystallins include at least five different proteins, while gamma-crystallins are monomeric with several identified in bovine and rat lens.
Alpha-crystallin comprises about 40% of total lens protein composition and functions as a chaperone to prevent protein aggregation, potentially reducing cataract formation.
Phosphorylated states of alpha-crystallin are believed to occur in response to cellular stress, serving structural and maintenance roles.
Alpha-B crystallin has been linked to Alexander’s disease, where it accumulates in brain cells of affected individuals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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