Thermo Fisher Scientific Ubiquilin 4 Polyclonal Antibody
Ubiquilin 4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB 및 IHC(P) 검증됨. 인간, 마우스, 랫트 반응성 보유. 액상, 비결합형, 1 mg/mL 농도. 단백질 분해 관련 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human UBQLN4 (Accession Q9NRR5), corresponding to amino acid residues V205–P255 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2818512 |
Product Specific Information
Antibody detects endogenous levels of total A1Up.
Target Information
The ubiquitin-proteosome pathway of protein degradation ensures proper cellular protein levels. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain-containing protein family is involved in proteosomal degradation. One such protein, CIP75 (ubiquilin-4), interacts with proteins such as Ataxin-1 and Connexin-43, increasing turnover rates. Overexpression of CIP75 reduces Connexin-43 half-life, while siRNA knockdown shows the opposite. CIP75 contains an N-terminal UbL domain interacting with the 26S proteosome complex and a C-terminal UBA domain mediating Connexin-75 interaction. At least three isoforms of CIP75 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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