Thermo Fisher Scientific AIFM3 Polyclonal Antibody
AIFM3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 적합하며 인간 및 생쥐 시료 반응성. 고순도 Affinity chromatography 정제, -20°C 보관, 연구용 전용.
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human AIFM3 (Accession Q96NN9), corresponding to amino acid residues P10–P60 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818514 |
Product Specific Information
Antibody detects endogenous levels of total AIFL.
Target Information
Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover as well as tumor formation. Recently, a protein similar to apoptosis-inducing factor (AIF) was cloned and designated AIFL (also known as AIFM3).
AIFM3 is expressed ubiquitously and is predominantly localized to the inner membranes of mitochondria. Unlike AIF, AIFM3 does not translocate to the nucleus upon induction of apoptosis. However, overexpression of AIFM3, like AIF, induces cytochrome c release from mitochondria, cleavage of caspase 3, and ultimately apoptosis, indicating AIFM3 induces apoptosis through caspase activation.
Multiple isoforms of AIFM3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-99581_AIFM3_Q96NN9-1_Rabbit.svg)
(이미지: PA5-99581_AIFM3_Q96NN9-1_Rabbit_PDP.jpeg)
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