Thermo Fisher Scientific CD107b (LAMP-2) Monoclonal Antibody (AC17)
개 및 비인간 영장류에서 CD107b(LAMP-2) 단백질을 검출하는 마우스 단클론 항체입니다. Western blot, ICC/IF, Flow cytometry, IP 등에 적합하며, Protein A로 정제된 액상 형태입니다. LAMP-2의 리소좀 관련 기능 연구에 활용됩니다.
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- MA528269
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100–1:500 | – |
| Immunocytochemistry (ICC/IF) | Assay-dependent | 2 publications |
| Flow Cytometry (Flow) | 1:50–1:200 | – |
| Immunoprecipitation (IP) | Assay-dependent | – |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Dog |
| Published Species | Dog, Non-human primate |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AC17 |
| Immunogen | MDCK (Madin-Darby Canine Kidney) cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745232 |
Additional Formats Available:
Product Specific Information
This antibody recognizes canine CD107b, also known as lysosome-associated membrane protein 2 (LAMP-2).
Target Information
LAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) belongs to a family of membrane glycoproteins. It provides selectins with carbohydrate ligands and may play roles in tumor metastasis, lysosomal maintenance, and adhesion.
Prior to posttranslational modification, LAMP2 is a ~46 kDa polypeptide; the mature form is extensively glycosylated, with a molecular weight of 100–130 kDa.
LAMP2 consists of a large intra-lysosomal domain, a hydrophobic transmembrane domain, and a short cytoplasmic tail. It is a marker for chaperone-mediated autophagy.
Three variants exist: LAMP-2A, LAMP-2B, and LAMP-2C. Together with CD107a/LAMP-1, LAMP2 is a major lysosomal membrane component essential for lysosome-phagosome fusion and phagosomal maturation.
Deficiency of LAMP2 leads to accumulation of autophagosomes and is associated with Danon’s disease (cardiomyopathy and myopathy).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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