Thermo Fisher Scientific CD107b (LAMP-2) Monoclonal Antibody (AC17), FITC

Thermo Fisher Scientific CD107b (LAMP-2) Monoclonal Antibody (AC17), FITC

Applications

• Flow Cytometry (Flow)

Tested Dilution: Neat
Publications: -

Product Specifications

Product Specific Information

This antibody recognizes canine CD107b, otherwise known as lysosome-associated membrane protein 2 or LAMP-2.

Target Information

LAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins. LAMP2 provides selectins with carbohydrate ligands and may play a role in tumor cell metastasis, as well as in protection, maintenance, and adhesion of lysosomes.
Prior to posttranslational modification, LAMP2 is approximately a 46 kDa polypeptide. Mature, functional LAMP2 is extensively glycosylated with various N-linked and O-linked oligosaccharides, resulting in a total molecular weight of about 100–130 kDa.
LAMP2 has a structure comprised of:

• A large amino-terminal intra-lysosomal domain
• A hydrophobic transmembrane domain
• A short carboxyl-terminal cytoplasmic tail

LAMP2 is used to monitor chaperone-mediated autophagy. It exists in three variant forms: LAMP-2A, LAMP-2B, and LAMP-2C.
Together with CD107a/LAMP-1, LAMP2 is a major constituent of lysosomal membranes, involved in lysosome biogenesis and fusion with phagosomes. LAMP2 deficiency leads to accumulation of autophagosomes and can cause cardiomyopathy and myopathy (Danon’s disease).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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